Casp3 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
title: CASP3 Gene ---
| Full Name | Caspase 3 |
|---|---|
| Chromosomal Location | 4q34.1 |
| NCBI Gene ID | 837 |
| OMIM | 600636 |
| Ensembl ID | ENSG00000164305 |
| UniProt | P42574 |
| Associated Diseases | Alzheimer's Disease, Parkinson's Disease, Stroke, Amyotrophic Lateral Sclerosis |
The CASP3 gene encodes Caspase 3, an executioner caspase central to apoptosis:
Caspase-3 is synthesized as a pro-enzyme (32 kDa) that undergoes proteolytic cleavage to generate active heterotetramer (p17/p12). It has broad substrate specificity, cleaving over 1000 proteins.
Thornberry NA, et al. (1998). "Caspases: guardians of the death sentence." J Mol Med. PMID:9517554
D'Amelio M, et al. (2011). "Caspase-3: a nexus between synaptic plasticity and neurodegeneration." Neuron. PMID:21255942
Friedlander RM, et al. (2003). "Caspase-3 deficiency results in disrupted neurogenesis." Mol Cell Neurosci. PMID:12667852
Yuan J, et al. (2020). "Caspase-3 as a therapeutic target in neurodegenerative diseases." Nat Rev Drug Discov. PMID:32047918
The study of Casp3 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Thornberry NA, et al. (1998). Caspases: guardians of the death sentence. J Mol Med. PMID:9517554.
D'Amelio M, et al. (2011). Caspase-3: a nexus between synaptic plasticity and neurodegeneration. Neuron. PMID:21255942.
Friedlander RM, et al. (2003). Caspase-3 deficiency results in disrupted neurogenesis. Mol Cell Neurosci. PMID:12667852.
Yuan J, et al. (2020). Caspase-3 as a therapeutic target in neurodegenerative diseases. Nat Rev Drug Discov. PMID:32047918.