Calm1 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
.infobox .infobox-gene
| Gene Symbol | CALM1 |
|---|---|
| Gene Name | Calmodulin 1 |
| Chromosome | 14q32.11 |
| NCBI Gene ID | 801 |
| OMIM ID | 114180 |
| Ensembl ID | ENSG00000143819 |
| UniProt ID | P0DP23 |
| Associated Diseases | Long QT Syndrome, Cataracts, Neurodevelopmental Disorders |
| --- | --- |
| Categories | Calcium Signaling, Synaptic Plasticity |
This section provides a comprehensive overview of the gene/protein and its role in the nervous system and neurodegenerative diseases.
Calmodulin 1 is a calcium-binding messenger protein that transduces calcium signals by binding calcium and modulating target protein activity. It is ubiquitously expressed and essential for many enzymes, channels, and transcription factors. CALM1 mutations cause cardiac arrhythmias (long QT syndrome) and cataracts. Calmodulin is crucial for calcium-dependent signaling in neurons.
The CALM1 gene is associated with several diseases.
The study of Calm1 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.