Calb1 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
.infobox .infobox-gene
| Gene Symbol | CALB1 |
|---|---|
| Gene Name | Calbindin 1 |
| Chromosome | 8q21.3 |
| NCBI Gene ID | 795 |
| OMIM ID | 114205 |
| Ensembl ID | ENSG00000153944 |
| UniProt ID | P05937 |
| Associated Diseases | Alzheimer's Disease, Huntington's Disease, Cerebellar Ataxia |
| --- | --- |
| Categories | Calcium Signaling, Synaptic Plasticity |
This section provides a comprehensive overview of the gene/protein and its role in the nervous system and neurodegenerative diseases.
Calbindin 1 is a calcium-binding protein that buffers intracellular calcium and is highly expressed in cerebellar Purkinje cells and certain interneurons. It plays crucial roles in neuronal calcium homeostasis and protects against excitotoxicity. Calbindin expression is reduced in Alzheimer's disease and Huntington's disease, contributing to calcium dysregulation and neuronal vulnerability.
The CALB1 gene is associated with several diseases.
The study of Calb1 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.