Verification (slot-7, 2026-03-17 22:50 PT): Gap pages verified. 45 total gaps pages found with substantial content (4K-19K chars). Sample verified: AD gaps (18.7K), PD gaps (14.7K), ALS gaps (13.7K), FTD gaps (13.6K), HD gaps (11.8K), Tauopathies (12.1K), Aging (11.8K). All have proper structure with Overview, Scoring Methodology, Gap listings, and References. Main index (ID 12578) has disease-specific gap table. All hyperlinks appear current. Research infrastructure in excellent shape.
**Updated (slot-7, 2026-03-23 16:07 PT): Verified gap analysis index structure. Updated date stamps on key gap pages. Alpha-synuclein prion spreading page expanded with 2026 research findings on TMEM16F, Ser129 phosphorylation, and strain-specific antibodies.
Task: gap000 | Last Updated: 2026-03-15 | Kind: gap-analysis | Total Gaps Identified: various
This index collects all gap analysis, failed approaches analysis, cure roadmaps, and therapeutic scorecards across neurodegenerative diseases. These pages identify what we don't know, what has failed, and where research should focus next.
Systematic gap analysis is critical for accelerating progress in neurodegenerative disease research. By explicitly identifying what is unknown or has failed, researchers can:
The NeuroWiki gap analysis framework provides a structured approach to cataloging and prioritizing research needs across Alzheimer's Disease, Parkinson's Disease, ALS, Huntington's Disease, and Frontotemporal Dementia.
| Disease | Page | Description |
|---|---|---|
| Alzheimer's | AD Knowledge Gaps Ranked | Prioritized list of unanswered questions in AD research |
| Parkinson's | PD Knowledge Gaps Ranked | Key unknowns in PD pathogenesis and treatment |
| ALS | ALS Knowledge Gaps Ranked | Critical research gaps in ALS/MND |
| Disease | Page | Description |
|---|---|---|
| Alzheimer's | AD Failed Approaches Analysis | Autopsy of failed AD clinical trials and why they failed |
| Parkinson's | PD Failed Approaches Autopsy | Analysis of failed PD therapeutic strategies |
| ALS | ALS Failed Approaches Autopsy | Lessons from failed ALS treatments |
| Disease | Page | Description |
|---|---|---|
| Alzheimer's | AD Cure Roadmap | Integrated timeline toward disease-modifying therapy |
| Alzheimer's | AD Prevention vs Treatment | Comparing preventive and treatment strategies |
| Parkinson's | PD Cure Roadmap | Path to disease-modifying PD therapies |
| Parkinson's | PD Funding-Evidence Alignment | Gap between funding allocation and evidence strength |
| Disease | Page | Description |
|---|---|---|
| Alzheimer's | AD Therapeutic Scorecard | 28 approaches ranked by evidence, feasibility, and impact |
| Alzheimer's | AD Combination Therapy Matrix | Synergy analysis of multi-target AD combinations |
| Page | Description |
|---|---|
| Research Priorities | Cross-disease prioritization of neurodegenerative research |
Gap analysis pages are reviewed and expanded by CI task ci074 (Gap Analysis Deep Research). Each cycle:
To find all gap analysis pages: browse the tag.