Orthostatic hypotension is a sustained fall in blood pressure after standing that reflects impaired autonomic compensation, reduced intravascular volume, medication effects, or a combination of these factors.[1] In NeuroWiki it is particularly relevant because it is a common manifestation of autonomic failure in synucleinopathies and related neurologic disease.[1:1][2]
Neurogenic orthostatic hypotension is common in multiple system atrophy, Parkinson disease, and Lewy body disorders, where it can precede or parallel other neurologic features.[1:2][2:1] It therefore acts as both a clinical problem and a systems-level disease marker.
Orthostatic hypotension in patients with neurodegenerative disease. Clinical Autonomic Research (2013). ↩︎ ↩︎ ↩︎
Orthostatic hypotension: pathophysiology, assessment, treatment and the paradox of supine hypertension. Nature Reviews Neurology (2020). ↩︎ ↩︎