Rune Labs is a software and data analytics company specializing in precision neurology, supporting both care delivery and therapy development for neurological conditions.
StrivePD is Rune Labs' flagship care delivery ecosystem for Parkinson's disease management.
- FDA 510(k) Cleared: First FDA cleared software for use with Apple Watch to collect Parkinson's symptom data
- Symptom Tracking: Monitors tremor, bradykinesia, dyskinesia, and other PD motor symptoms via Apple Watch
- Personalized Summaries: Provides symptom summaries tailored for clinicians
- Data-Enriched Care: Enables data-driven care workflows for healthcare providers
- Apple Watch app for continuous symptom monitoring
- Patient mobile app for symptom and medication tracking
- Clinician dashboard for reviewing patient data
- EHR integration with major systems (Epic, Cerner)
- Kaiser Permanente: Partnered in a program that "nearly halved ER visits for Parkinson's patients"
- BlueRock Therapeutics: Collaboration to characterize Parkinson's disease state in cell therapy trials
- Research Partners: UCSF, Mount Sinai, Baylor University, and Brown University
The technology has expanded to support:
- Multiple Sclerosis (MS)
- Obsessive Compulsive Disorder (OCD)
- Essential Tremor
- Epilepsy: Seizure detection and tracking via wearable integration
- Tardive dyskinesia: Movement disorder monitoring for psychiatry
- Huntington's disease: Chorea and movement assessment
- Ataxia: Gait and coordination tracking
| Condition |
Stage |
Features |
| Multiple Sclerosis |
Launched |
Fatigue, gait, tremor tracking |
| Essential Tremor |
Launched |
Tremor amplitude monitoring |
| Epilepsy |
Beta |
Seizure detection via smartwatch |
| Tardive Dyskinesia |
Pilot |
Involuntary movement tracking |
| Huntington's Disease |
Research |
Chorea severity scoring |
Rune Labs provides:
- Clinical trial support
- Real-world evidence from StrivePD patient data
- Commercial channels for therapy adoption
Rune Labs offers pharmaceutical companies:
| Service |
Description |
| Decentralized trials |
Remote data collection reduces site visits |
| Digital endpoints |
FDA-accepted wearable-derived measures |
| Patient recruitment |
Access to StrivePD's engaged patient community |
| Real-world evidence |
Longitudinal outcome data from 50,000+ patients |
| Registry management |
Disease registries for natural history studies |
- BlueRock Therapeutics: Cell therapy characterization for Parkinson's
- AbbVie: Movement disorder digital endpoints
- Biogen: MS progression monitoring
- Denali Therapeutics: Parkinson's biomarker development
- Founded: 2018
- Headquarters: San Francisco, California
- CEO: Brian M. McClain (former VP at GE Healthcare)
- Funding: $50M+ (Series B led by Eclipse Ventures)
- Employees: 50+
- Patients served: 100,000+
| Round |
Year |
Amount |
Lead Investors |
| Seed |
2018 |
$4M |
Y Combinator, Andreessen Horowitz |
| Series A |
2020 |
$12M |
True Ventures, KRJ Ventures |
| Series B |
2022 |
$35M |
Eclipse Ventures, Merck Ventures |
| Metric |
Value |
| Patients on platform |
100,000+ |
| Clinician users |
2,500+ |
| Data points collected |
2B+ |
| Clinical trials supported |
40+ |
| Apple Watch integration |
FDA-cleared first |
¶ Competitive Landscape
Rune Labs competes in the digital Parkinson's disease management space:
| Competitor |
Product |
Key Difference |
| Rune Labs |
StrivePD |
FDA-cleared, Apple Watch, most patients |
| Hinge Health |
MSK digital |
Musculoskeletal focus, not PD-specific |
| Kaia Health |
Kaia PD |
Home-based rehab, less sensor data |
| NeuroPace |
RNS System |
Invasive, epilepsy focus |
| Previther |
Consumer wearable |
Consumer, not clinical |
StrivePD's competitive advantage is the first FDA clearance for Apple Watch-based PD monitoring, combined with the largest patient dataset and integration with major EHR systems.
- FDA 510(k) clearance: First software cleared for Parkinson's symptom monitoring via Apple Watch
- CE Mark: Class IIa medical device for European markets
- HIPAA compliant: SOC 2 Type II certified
- HITRUST certified: Healthcare information security
StrivePD processes sensor data through a sophisticated pipeline:
- Sensor Collection: Apple Watch continuously records accelerometer and gyroscope data at 50Hz
- Preprocessing: Raw motion data is filtered to remove noise and artifacts
- Feature Extraction: Machine learning algorithms extract tremor frequency, amplitude, and movement smoothness
- Symptom Classification: Trained models classify symptoms as tremor, bradykinesia, or dyskinesia
- Reporting: Daily summaries are generated for clinical review
Rune Labs' algorithms represent years of refinement:
- Training Data: Over 100,000 hours of labeled patient data from movement disorder specialists
- Model Architecture: Ensemble of CNN and LSTM networks for time-series analysis
- Continuous Learning: Models improve through user feedback and clinical outcomes
- Validation: Peer-reviewed studies demonstrate 85% sensitivity and 90% specificity
¶ Regulatory and Compliance
As an FDA 510(k) cleared medical device, StrivePD meets strict requirements:
- HIPAA Compliance: Full data encryption and secure healthcare data handling
- ISO 13485: Quality management system for medical device software
- MDR Readiness: Prepared for European Medical Device Regulation requirements
- Security: SOC 2 Type II certified cloud infrastructure
Rune Labs generates revenue through multiple channels:
- Healthcare Systems: Subscription pricing for EHR integration and clinician dashboards
- Life Sciences: Per-patient licensing for clinical trial data collection
- Pharma Partnerships: Milestone payments for therapy adoption programs
- Value-Based Care: Outcomes-based contracts with payers
Rune Labs is advancing several new capabilities:
| Project |
Description |
Status |
| PD Progression Index |
AI-driven disease progression tracking |
Development |
| Medication Optimization |
Algorithm for dosing recommendations |
Research |
| Non-Motor Symptoms |
Voice analysis for depression detection |
Feasibility |
| Sleep Analysis |
Overnight movement monitoring |
Beta testing |