Neurons expressing ubiquitin C-terminal hydrolase L1 are involved in protein degradation and neurodegeneration.
| Property |
Value |
| Category |
Ubiquitin System Enzymes |
| Location |
Neurons (pan-neuronal marker) |
| Enzyme |
UCHL1 |
| Function |
Protein degradation |
- Hydrolase: Ubiquitin recycling
- Ligase: Monoubiquitin formation
- Dimerization: Functional form
- Neuronal: Highly enriched
- Neuroendocrine: Also expressed
- Specific: Not in glia
- Ubiquitin cycle: Recycling
- Degradation: Proteasome pathway
- Autophagy: Selective autophagy
- Axonal transport: Role in trafficking
- Synaptic function: Pre-synaptic localization
- Neuronal survival: Protection
- UCHL1 mutations: Link to familial PD
- Enzyme activity: Reduced in PD
- Therapeutic: UCHL1 enhancement
- Aggregation: UCHL1 in plaques
- Dysfunction: Enzyme activity changes
- Biomarker: CSF UCHL1
- Larsen. UCHL1 structure (1996)
- Liu. UCHL1 in neurodegeneration (2002)