Tuberomammillary Nucleus Expanded is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
The Tuberomammillary Nucleus (TMN) is the sole source of histamine in the mammalian brain, located in the posterior hypothalamus. It plays crucial roles in wakefulness, arousal, and is significantly affected in neurodegenerative diseases.
| Property | Value |
|---|---|
| Category | Hypothalamus / Arousal System |
| Location | Posterior hypothalamus, ventral to mammillary bodies |
| Function | Histaminergic neurotransmission, wakefulness, arousal |
| Diseases | Alzheimer's Disease, Parkinson's Disease, Narcolepsy, Multiple System Atrophy |
The TMN is composed of histaminergic neurons that project widely throughout the brain. It contains approximately 64,000 neurons in humans.
Core TMN
Extended TMN
The study of Tuberomammillary Nucleus Expanded has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
[1] [1] Haas HL. Histamine in the brain. Neuropharmacology. 2020.
[2] [2] Saper CB. Sleep state switching. Neuron. 2010.
[3] [3] Passani MB. Histamine in the brain. Front Syst Neurosci. 2011.
[4] [4] Shan L. Alterations in the histaminergic system in Alzheimer's disease. Acta Neuropathol. 2012.
[5] [5] Kotei P. Histamine and neurodegenerative diseases. Cell Mol Neurobiol. 2019.
[6] [6] Valko PO. Tuberomammillary nucleus volume in narcolepsy. Sleep. 2013.
[7] [7] Fr凳ki A. Histamine in sleep disorders. J Neural Transm. 2020.
[8] [8] Bacher C. H3 receptor antagonists for Alzheimer's disease. CNS Drugs. 2021.