TPH is the rate-limiting enzyme in serotonin synthesis.
| Property |
Value |
| Category |
Indoleamine Neurons |
| Location |
Raphe nuclei |
| Enzyme |
Tryptophan hydroxylase |
| Transmitter |
Serotonin |
- TPH: Rate-limiting
- TPH1: Peripheral
- TPH2: Neural
- TPH1: Intestine, mast cells
- TPH2: CNS neurons
- Alternative splicing: Regulation
- Dorsal raphe: Mood
- Median raphe: Memory
- Projections: Widespread
- Rostral: Forebrain
- Caudal: Spinal cord
- Serotonin: Modulation
- Depression: TPH changes
- SSRI: TPH targeting
- Therapeutic: Increase 5-HT
- REM sleep: 5-HT role
- Sleep-wake: Transitions
- Wakefulness: Arousal
- TPH: Genetic variants
- SSRI: Increase 5-HT
- Therapeutic: TPH targeting
- TPH2: Polymorphism
- Serotonin: Migraine
- Therapeutic: 5-HT targeting
- Lovenberg. TPH discovery (1967)
- Walther. TPH2 in brain (2003)