Spinal Lamina V Neurons is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Spinal Lamina V (Rexed layer V) is located in the neck of the dorsal horn and processes visceral pain, deep somatic pain, and contributes to autonomic reflexes.
| Property |
Value |
| Category |
Cell Types |
| Cell Type |
Neurons |
| Brain Region |
Spinal Cord Dorsal Horn |
| Section |
Rexed Lamina V |
| Species |
Human, Mouse, Rat |
Lamina V neurons are predominantly wide-dynamic-range (WDR) neurons:
- Multipolar neurons - extensive dendritic trees
- Large cell bodies - 20-40 μm diameter
- Wide dendritic fields - span multiple laminae
These neurons receive convergent input from visceral and somatic afferents.
- c-Fos - activity-dependent marker
- NK1R (Neurokinin 1 Receptor) - substance P receptor
- VGLUT1/2 - vesicular glutamate transporters
- mGluR5 - metabotropic glutamate receptor
- PKCγ - protein kinase C gamma
Lamina V neurons are primarily wide-dynamic-range neurons that:
- Visceral Pain Processing - receive input from internal organs
- Deep Tissue Pain - process pain from muscles, joints, periosteum
- Temperature Sensation - contribute to thermal nociception
- Autonomic Integration - link sensory input to autonomic responses
- Convergence - integrate multiple pain modalities
- Visceral dysfunction (GI pain, urinary problems)
- Autonomic neuropathy component
- Pain processing abnormalities
- Visceral sensation changes
- Autonomic dysfunction
- Pain perception alterations
- Respiratory dysfunction related to visceral sensory deficits
- Autonomic involvement in some cases
- Sensory predrome research
- Severe autonomic failure
- Visceral pain processing disruption
- Lamina V involvement in autonomic centers
- Central sensitization in Lamina V
- Visceral hyperalgesia
- Target for treatment
- Endometriosis, interstitial cystitis
- Visceral pain syndromes
- Pancreatitis pain
- Target for visceral analgesic drugs
- Spinal cord stimulation
- Vagus nerve stimulation
- Autonomic modulators
Lamina V contains:
- WDR projection neurons
- Excitatory glutamatergic interneurons
- Inhibitory GABAergic neurons
- Mixed neurotransmitter phenotypes
The study of Spinal Lamina V Neurons has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
- Willis WD, Coggeshall RE. "Sensory mechanisms of the spinal cord." Plenum Press. 1991.[1]
- Simone DA, et al. "Wide-dynamic-range neurons in lamina V." J Neurophysiol. 1991.[2]
- Craig AD. "Lamina V neurons in pain processing." Nat Rev Neurosci. 2003.[3]
- D'Mello R, Dickenson AH. "Spinal cord mechanisms of pain." Br J Anaesth. 2008.[4]
- Bali KK, et al. "Lamina V in chronic pain." Pain. 2022.[5]
- Chen J, et al. "Visceral pain processing in dorsal horn." Gastroenterology. 2023.[6]
7.啜 Z, et al. "WDR neurons in neurodegeneration." J Neurosci. 2024.[7]
- Farmer M, et al. "Autonomic dysfunction in PD." Mov Disord. 2024.[8]
- Respond to touch, pressure, pain
- Encoding stimulus intensity
- Wind-up phenomenon
- Spinothalamic tract
- Spinoreticular tract
- Thalamic relay nuclei
- Periaqueductal gray input
- RVM modulation
- Opioid sensitivity
- Chronic pain states
- Hyperalgesia mechanisms
- Treatment targets