Spinal Cord Lamina I Pain Neurons is an important cell type in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Lamina I neurons in the spinal cord dorsal horn are critical for pain transmission and thermoreception.
| Property |
Value |
| Category |
Spinal cord |
| Location |
Dorsal horn, lamina I |
| Cell Type |
Projection neurons |
| Neurotransmitter |
Glutamate, substance P |
| Function |
Pain and temperature |
- Spinothalamic tract cells: Pain to thalamus
- Spinoparabrachial cells: Emotion of pain
- Neurokinin 1 receptor: Substance P target
- Excitatory: Glutamatergic
- Inhibitory: GABAergic/glycinergic
- Modulation: Pain gate control
- Primary afferents: A-delta and C fibers
- Transduction: TRPV1, ASIC channels
- Transmission: Glutamate release
- Central sensitization: Hyperactivity
- Neuropathic pain: Nerve injury
- Inflammatory pain: Tissue damage
- Motor neuron disease: Includes pain pathways
- Spinal cord involvement: Widespread
- Sensory abnormalities: Common
- Pain: Non-motor symptom
- Central processing: Altered
- Dyskinesia-related: Medication effects
- Nav1.7/1.8: Pain relief
- TRPV1: Capsaicin effects
- ASIC3: Inflammatory pain
- Opioid receptors: Morphine
- NK1 receptor: Substance P
- GluN2B: NMDA modulation
The study of Spinal Cord Lamina I Pain Neurons has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
- Todd. Lamina I neurons (2010)
- Craig. Pain and temperature (2003)
- Woolf & Mannion. Neuropathic pain (1999)