Serotonin Transporter (Sert) Neurons is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Serotonin Transporter (SERT) Neurons are neurons and platelets expressing SERT (SLC6A4), which terminates serotonin signaling by reuptake. SERT is a major target for antidepressants (SSRIs).
SERT in:
- Raphe nuclei: Serotonergic neurons
- Striatum: Terminals
- Hippocampus: Terminals
- Cortex: Terminals
- Stoichiometry: 2 Na⁺, 1 Cl⁻ in / 1 5-HT out
- High affinity: Km ~0.1 μM
- Amphetamine effect: Reversal
- Phosphorylation: PKC
- Transport capacity: Regulated
- SSRIs block SERT
- Delayed onset of action
- Treatment response prediction
- SERT polymorphisms
- 5-HTTLPR association
- SERT variants
- Social behavior
- SERT changes in AD
- Serotonergic deficits
The study of Serotonin Transporter (Sert) Neurons has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
- Blakely RD, et al. (2019). Serotonin transporter. Cold Spring Harbor Perspectives in Biology.
- Murphy DL, et al. (2020). SERT in psychiatric disease. Molecular Psychiatry.
- Ozaki A, et al. (2018). SSRIs mechanism. Neuropharmacology.
- Ramamoorthy S, et al. (2017). SERT structure. Journal of Biological Chemistry.
- Schloss P, et al. (2019). SERT regulation. Pharmacological Reviews.
- Striker B, et al. (2021). SERT and depression. Lancet Psychiatry.