Rostral Migratory Stream Neural Progenitors is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
The Rostral Migratory Stream (RMS) is a specialized pathway in the adult brain through which neural progenitor cells migrate from the subventricular zone (SVZ) to the olfactory bulb. It represents the major neurogenic niche in the adult mammalian brain.
| Property | Value |
|---|---|
| Category | Neurogenic Niche |
| Location | From lateral ventricles through the olfactory bulb |
| Cell Types | Neuroblasts, astrocytes, ependymal cells |
| Neurotransmitter | GABA, Glutamate (mature neurons) |
| Key Markers | DCX, PSA-NCAM, Nestin, GFAP |
The RMS consists of:
Key genes in RMS:
The study of Rostral Migratory Stream Neural Progenitors has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
[1] Lois C, Alvarez-Buylla A. Long-distance neuronal migration in the adult mammalian brain. Science. 1994;264(5162):1145-1148.
[2] Doetsch F, García-Verdugo JM, Alvarez-Buylla A. Cellular composition and three-dimensional organization of the subventricular germinal zone in the adult mammalian brain. J Neurosci. 1997;17(13):5046-5061.
[3] Whitman MC, Fan W, Rela L, et al. Blood vessels form a migratory scaffold in the rostral migratory stream. J Comp Neurol. 2009;516(2):94-104.
[4] Ming GL, Song H. Adult neurogenesis in the mammalian central nervous system. Annu Rev Neurosci. 2005;28:223-250.
[5] Lledo PM, Alonso M, Grubb MS. Adult neurogenesis and functional plasticity in neuronal circuits. Nat Rev Neurosci. 2006;7(3):179-193.
[6] Winner B, Cooper-Kuhn CM, Aigner R, et al. Long-term survival and cell death of newly generated neurons in the adult rat olfactory bulb. Eur J Neurosci. 2002;16(9):1681-1689.
[7] Petreanu L, Alvarez-Buylla A. Maturation and death of adult-born olfactory bulb granule neurons: role of experience. Eur J Neurosci. 2002;16(9):1701-1709.
[8] Belvindrah R, Hankel S, Walker J, et al. Beta1 integrin signaling on neurons generates the myelin sheath. Nat Neurosci. 2017;20(11):1569-1576.