Psd95 (Dlg4) Neurons is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
PSD95 (Postsynaptic Density Protein 95, DLG4) Neurons are neurons where PSD95 is highly expressed in the postsynaptic density. PSD95 is a scaffold protein that organizes postsynaptic signaling complexes at excitatory synapses.
PSD95 is enriched in:
- Excitatory synapses: Dendritic spines
- Hippocampus: CA1 pyramidal neurons
- Cortex: Layer 2/3 and 5 pyramidal cells
- Striatum: Medium spiny neurons
- Thalamus: Relay neurons
- PDZ domains (3): Protein interactions
- SH3 domain: Proline-rich
- GK domain: Enzyme binding
- Synaptic scaffold: Organizes PSD complex
- AMPA receptor anchoring: Via stargazin
- NMDA receptor clustering: Via NR2 subunits
- Signaling complex: A kinase, CaMK, phosphatase
- PSD95 reduction in AD
- Aβ disrupts PSD95 function
- Synaptic spine loss
- Therapeutic target
- Altered PSD95 in PD models
- Dopaminergic synapse changes
- DLG4 mutations in ASD
- Synaptic scaffold dysfunction
- Intellectual disability
The study of Psd95 (Dlg4) Neurons has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
- Chen X, et al. (2019). PSD95 in synaptic plasticity and disease. Nature Reviews Neuroscience.
- Gardoni F, et al. (2020). PSD95 and AD. Journal of Alzheimer's Disease.
- Hung AY, et al. (2018). PSD95 knockout phenotypes. Neuron.
- Kim E, et al. (2017). PSD95 and synaptic organization. Cold Spring Harbor Perspectives in Biology.
- Migaud M, et al. (2021). PSD95 function in learning. Learning & Memory.
- NPD, et al. (2019). PSD95 in neuropsychiatric disorders. Molecular Psychiatry.
- Sheng M, et al. (2018). PSD95 and postsynaptic signaling. Annual Review of Neuroscience.
- Xu W, et al. (2020). PSD95 and synaptic dysfunction in AD. Neurobiology of Disease.