PNMT neurons produce epinephrine from norepinephrine in the adrenal medulla and brain.
| Property |
Value |
| Category |
Catecholamine Neurons |
| Location |
Adrenal medulla, Solitary tract |
| Enzyme |
PNMT |
| Transmitter |
Epinephrine |
- PNMT: Phenylethanolamine N-methyltransferase
- S-adenosylmethionine: Methyl donor
- Glucocorticoids: Induction
- Norepinephrine: Substrate
- Epinephrine: Product
- Cofactors: Requires SAM
- Chromaffin cells: Main source
- Stress response: Epinephrine release
- Sympathetic: Fight or flight
- Solitary nucleus: C2 neurons
- Vagus: Afferent integration
- Lateral tegmentum: Small population
- Fight or flight: Epinephrine
- Heart: Cardiac output
- Glucose: Glycogenolysis
- Lipolysis: Fat mobilization
- Glycogenolysis: Glucose release
- Thermogenesis: Brown fat
- PNMT: Stress response
- Epinephrine: Anxiety
- Therapeutic: Beta-blockers
- PNMT: Tumor marker
- Epinephrine: Excess
- Diagnosis: MN, NMN
- Axelrod. PNMT enzyme (1962)
- Wurtman. PNMT regulation (2002)