Paraneoplastic cerebellar degeneration (PCD) causes subacute cerebellar ataxia due to immune attack on Purkinje cells.
PCD:
- Paraneoplastic syndrome
- Anti-Yo, anti-Hu, anti-Tr etc.
- Usually precedes cancer diagnosis
- Often severe deficits
- Primary target
- Severe loss
- Dendritic degeneration
- Axonal "torpedoes"
- Secondary involvement
- Input disruption
- Parallel fiber changes
- Output disruption
- Degeneration
- Connected structures
¶ Antibody Types
- Anti-Yo (gynecologic cancer)
- Anti-Hu (SCLC)
- Anti-Tr (lymphoma)
- Anti-mGluR1 (Hodgkin's)
- Direct Purkinje cell attack
- Cytotoxic T cells
- Complement
- Rapid progression
- Severe gait instability
- Limb ataxia
- Dysarthria
- Dysphagia
- Ocular findings
- Ovarian, breast
- SCLC
- Hodgkin's lymphoma
- Primary approach
- Often present
- Essential
- Limited efficacy
- Often poor response
- May stabilize
- Often poor
- May stabilize with treatment
- Often permanent deficits
- Paraneoplastic cerebellar degeneration (2022)
- Anti-Purkinje cell antibodies (2021)