Opsoclonus-myoclonus ataxia syndrome (OMS) is an immune-mediated disorder causing characteristic eye movements and movement disorders.
OMS:
- Paraneoplastic (neuroblastoma)
- Post-viral
- Often pediatric
- Good prognosis with treatment
- Purkinje cells
- Deep nuclei
- Ataxia mechanism
- Oculomotor nuclei
- Saccadic generation
- Eye movement control
- Anterior horn cells
- Myoclonus generation
- Motor neurons
¶ Antibody Targets
- Anti-neuronal nuclear antibodies
- Anti-cytoplasmic
- Purkinje cell antibodies
- Purkinje cell loss
- Output disruption
- Ataxia mechanism
- Saccadic eye movements
- Horizontal and vertical
- Characteristic
- Involuntary jerks
- Variable severity
- Action-induced
- Gait instability
- Limb ataxia
- Can be severe
- If neuroblastoma present
- Essential for outcome
- Corticosteroids
- IVIG
- Rituximab
-cyclophosphamide
- Often good with treatment
- May have residual deficits
- Relapse possible
- Opsoclonus-myoclonus (2022)
- Paraneoplastic cerebellar degeneration (2021)