Neuropeptide Y (NPY) Y1 receptor-expressing neurons are widely distributed throughout the brain and play crucial roles in energy homeostasis, stress response, and neurodegeneration.
The Y1 receptor (NPY1R) is one of the most widely expressed NPY receptors in the central nervous system. Neurons expressing NPY1R are involved in:
Y1 receptor neurons are found in:
Y1 receptor signaling may modulate amyloid-beta toxicity and neuroinflammation. Studies suggest NPY has neuroprotective effects via Y1R activation.
NPY-Y1R signaling may protect dopaminergic neurons in the substantia nigra pars compacta from degeneration.
Y1R agonists are being explored as potential neuroprotective agents in neurodegenerative disorders.