Normal pressure hydrocephalus (NPH) causes gait disturbance, cognitive decline, and urinary incontinence due to ventricular enlargement.
Idiopathic NPH (iNPH) is characterized by ventriculomegaly with normal opening pressure, affecting periventricular neurons.
- Adjacent to lateral ventricles
- Compression effects
- White matter changes
- Executive dysfunction
- Gait-related circuits
- Working memory deficits
- Memory impairment
- CA1 vulnerability
- Compression effects
- Gait circuitry
- Urinary control
- Frontal connections
- Impaired absorption
- Ventricular enlargement
- Periventricular stress
- Periventricular ischemia
- White matter rarefaction
- Subcortical hypoperfusion
- Direct neuronal compression
- Axonal injury
- Connectome disruption
- Magnetic gait
- Falls
- Most responsive to treatment
- Frontal/executive
- Memory relatively preserved
- Subcortical pattern
- Urgency
- Frequency
- Late feature
- NPH pathophysiology (2022)
- iNPH neuropathology (2021)