Neurokinin A (NK2) Receptor Neurons are neurons expressing the NK2 receptor, a member of the Tachykinin receptor family. These receptor neurons play crucial roles in smooth muscle contraction, gut motility and are implicated in various neurological and neurodegenerative conditions.
| Property | Value |
|---|---|
| Receptor Type | NK2 |
| Family | Tachykinin |
| Signaling Mechanism | Gq protein-coupled, activates phospholipase C |
| Primary Location | Hippocampus, cortex, peripheral nervous system |
Neurokinin A (NK2) Receptor Neurons are involved in Smooth muscle contraction, gut motility. These neurons express the NK2 receptor which gq protein-coupled, activates phospholipase c. The receptor's location in hippocampus, cortex, peripheral nervous system allows it to modulate neurotransmission and cellular signaling in key brain regions.
The NK2 receptor signals through gq protein-coupled, activates phospholipase c. This mechanism allows rapid or modulatory responses depending on the cellular context and co-expression of other receptors.
Irritable bowel syndrome, bladder dysfunction. Understanding the role of these receptor neurons provides insight into potential therapeutic targets for these conditions.
The NK2 receptor is a target for drug development in: