Substance P (NK1) Receptor Neurons are neurons expressing the NK1 receptor, a member of the Tachykinin receptor family. These receptor neurons play crucial roles in pain transmission, mood regulation, nausea and are implicated in various neurological and neurodegenerative conditions.
| Property | Value |
|---|---|
| Receptor Type | NK1 |
| Family | Tachykinin |
| Signaling Mechanism | Gq protein-coupled, activates phospholipase C |
| Primary Location | Amygdala, hippocampus, striatum, spinal cord |
Substance P (NK1) Receptor Neurons are involved in Pain transmission, mood regulation, nausea. These neurons express the NK1 receptor which gq protein-coupled, activates phospholipase c. The receptor's location in amygdala, hippocampus, striatum, spinal cord allows it to modulate neurotransmission and cellular signaling in key brain regions.
The NK1 receptor signals through gq protein-coupled, activates phospholipase c. This mechanism allows rapid or modulatory responses depending on the cellular context and co-expression of other receptors.
Depression, anxiety, chronic pain, chemotherapy nausea. Understanding the role of these receptor neurons provides insight into potential therapeutic targets for these conditions.
The NK1 receptor is a target for drug development in: