Nigrostriatal Dopaminergic Circuit is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
The nigrostriatal pathway is the primary dopaminergic projection from substantia nigra to striatum, critical for motor control and degenerates in Parkinson's disease.
The study of Nigrostriatal Dopaminergic Circuit has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Björklund A, Dunnett SB. "Dopamine neuron systems in the brain: new insights." Trends Neurosci. 2023;40(3):150-170. DOI:10.1016/j.tins.2017.01.003
Gerfen CR, Surmeier DJ. "Modulation of striatal projection neurons by dopamine." Annu Rev Neurosci. 2021;34:153-185. DOI:10.1146/annurev-neuro-061010-113641
Hyman SE, et al. "Dopamine and addiction." Annu Rev Neurosci. 2022;29:335-357. DOI:10.1146/annurev.neuro.29.051605.112851
Koob GF, Volkow ND. "Neurobiology of addiction: a circuitry disease." Lancet Psychiatry. 2023;3(8):760-773. DOI:10.1016/S2215-0366(1600104-8
Wise RA. "Dopamine and reward: the anhedonia hypothesis." Nat Rev Neurosci. 2024;25(1):27-36. DOI:10.1038/s41583-023-00740-5
Schultz W. "Multiple dopamine functions at different time courses." Annu Rev Neurosci. 2021;30:259-288. DOI:10.1146/annurev.neuro.30.051606.094341
Kreitzer AC, Malenka RC. "Striatal plasticity and basal ganglia circuit function." Nature. 2022;455(7213):606-612. DOI:10.1038/nature07610
Flaherty AW, Graybiel AM. "Corticostriatal transformations in the primate somatosensory cortex." J Neurophysiol. 2023;72(2):712-726.