Metabotropic glutamate receptor 5 (mGluR5) is a Group I mGluR involved in synaptic plasticity and disease.
| Property |
Value |
| Category |
Metabotropic Glutamate Receptors |
| Location |
Postsynaptic, Excitatory neurons |
| Receptor Type |
mGluR5 (GRM5) |
| Signaling |
Gq-coupled, excitatory |
- Class C: Like GABA-B
- Dimerization: Functional unit
- Cysteine-rich: Extracellular domain
- Hippocampus: High expression
- Striatum: Medium spiny neurons
- Cortex: Pyramidal cells
- PLC activation: Phospholipase C
- IP3/DAG: Calcium release
- PKC: Protein kinase C
- Calcium: Intracellular release
- ERK/MAPK: Gene expression
- mTOR: Protein synthesis
- LTP: mGluR5-dependent
- LTD: mGluR5-mediated
- Learning: mGluR5 in memory
- Motor coordination: Cerebellum
- Pain: Nociception
- Addiction: Cocaine effects
- mGluR5 theory: FXS
- mGluR5 antagonists: Therapeutic
- ADAR2: Clinical trials
- mGluR5: Dysregulation
- PAMs: Positive allosteric modulators
- Therapeutic: mGluR5 targeting
- mGluR5: Antagonists
- Dyskinesia: mGluR5 role
- L-DOPA: Long-term effects
- Niswender. mGluR5 (2010)
- Huber. mGluR5 in disease (2017)