Medial Amygdala (Mea) Neurons is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
The Medial Amygdala is a critical component of the extended amygdala that processes social and emotional information, particularly related to pheromones, mating, and stress responses. These neurons are highly relevant to neurodegenerative diseases that affect emotional regulation.
| Property | Value |
|---|---|
| Cell Type Name | Medial Amygdala (MeA) Neurons |
| Location | Medial aspect of the amygdala, rostral to the cortical nucleus |
| Neurotransmitter | GABA, Neuropeptides (CRF, oxytocin, vasopressin) |
| Lineage | GABAergic neuron > extended amygdala |
| Marker Genes | ESR1, ESR2, PR, CRF, OXT, AVP, GAD1, GAD2, NPY |
| Brain Regions | Olfactory bulb, VNO, Hypothalamus, BNST, Hippocampus |
Medial Amygdala neurons have distinctive features:
The Medial Amygdala processes socio-emotional information:
The study of Medial Amygdala (Mea) Neurons has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Meredith M. Vomeronasal, olfactory, hormonal convergence in the brain. Ann N Y Acad Sci. 1998;855:349-361. PMID:9925136 ↩︎
Choi GB, Dong HW, Murphy AJ, et al. Lhx6 delineates a pathway mediating innate reproductive behaviors from the amygdala to the hypothalamus. Neuron. 2005;46(4):647-660. PMID:15924832 ↩︎
Davis M, Shi C. The extended amygdala: of the bed is the medial division nucleus of the stria terminalis important in fear and anxiety? Ann N Y Acad Sci. 1999;877:281-296. PMID:10415655 ↩︎
McEwen BS, Akama KT, Alves SE, et al. Estrogen effects on the brain: actions beyond the hypothalamus. Ann N Y Acad Sci. 1995;765:1-16. PMID:7486033 ↩︎
Paschall GY, Davis M. Olfactory-mediated fear conditioning. II. Neural lesions of the olfactory cortex and amygdala impair fear conditioning. Behav Neurosci. 2002;116(1):64-73. PMID:11895178 ↩︎
van der Staay FJ, Day MJ. Emotions in animals and humans: relevance for understanding neuropsychiatric disease. Behav Brain Res. 2009;200(2):255-259. PMID:19138677 ↩︎
Braak H, Braak E. Evolution of neuronal changes in the course of Alzheimer's disease. J Neural Transm Suppl. 1998;54:137-143. PMID:9564603 ↩︎
Devanand DP, et al. Olfactory identification deficits predict progression to Alzheimer's disease. Ann Neurol. 2000;47(1):90-97. PMID:10632104 ↩︎
Lyketsos CG, et al. Neuropsychiatric symptoms in Alzheimer's disease. Int Psychogeriatr. 2000;12(1):131-137. PMID:10875140 ↩︎
Aarsland D, et al. Depression in Parkinson disease. Epidemiology, pathophysiology, and management. Drugs. 2010;70(5):545-560. PMID:20329802 ↩︎
Haehner A, et al. Olfactory loss in Parkinson's disease. J Neurol Sci. 2009;289(1-2):44-47. PMID:18771771 ↩︎
Voon V, et al. Impulse control disorders in Parkinson disease. Ann Neurol. 2011;69(6):986-996. PMID:21416496 ↩︎
Gorman JM, Kent JM. Anxiety and panic: brain mechanisms and treatment. J Clin Psychiatry. 2000;61(8):607-614. PMID:10968850 ↩︎
Rauch SL, Shin LM, Phelps EA. Neurocircuitry models of PTSD and functional neuroimaging. Ann N Y Acad Sci. 2006;1071:176-189. PMID:16891573 ↩︎
McEwen BS. Physiology and neurobiology of stress and adaptation: central role of the brain. Physiol Rev. 2007;87(3):873-904. PMID:17615391 ↩︎