Hypothalamic Pomc And Cart Neurons is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Proopiomelanocortin (POMC) and cocaine- and amphetamine-regulated transcript (CART) neurons in the arcuate nucleus are crucial for energy homeostasis and show alterations in neurodegenerative conditions.
POMC/CART neurons are anorexigenic (appetite-suppressing) neurons in the arcuate nucleus that respond to leptin and other metabolic signals. They project throughout the brain including to areas affected in neurodegeneration.
The study of Hypothalamic Pomc And Cart Neurons has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Cowley MA, Smart JL, Rubinstein M, et al. Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus. Nature. 2001;411(6836):480-484. PMID:11373681.
Cone RD. Anatomy and regulation of the central melanocortin system. Nat Neurosci. 2005;8(5):571-578. PMID:15856065.
Elias CF, Lee C, Kelly J, et al. Leptin activates hypothalamic CART neurons projecting to the spinal cord. Neuron. 1998;21(6):1375-1385. PMID:9883723.
Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature. 1994;372(6505):425-432. PMID:7984236.
Schwartz MW, Woods SC, Porte D Jr, Seeley RJ, Baskin DG. Central nervous system control of food intake. Nature. 2000;404(6778):661-671. PMID:10766253.
Morton GJ, Cummings DE, Baskin DG, Barsh GS, Schwartz MW. Central nervous system control of food intake and body weight. Nature. 2006;443(7109):289-295. PMID:17013213.
Belgardt BF, Bruning JC. CNS leptin and insulin action in the control of energy homeostasis. Nat Rev Endocrinol. 2010;6(6):323-332. PMID:20357766.
Dietrich MO, Horvath TL. Hypothalamic POMC neurons - publishing or perish. Nat Neurosci. 2012;15(11):1443-1445. PMID:23115172.