The tuberomammillary nucleus (TMN) is the sole source of histamine in the brain.
| Property |
Value |
| Category |
Histaminergic Neurons |
| Location |
Hypothalamus |
| Cell Type |
Histaminergic neurons |
| Neurotransmitter |
Histamine |
- HDC: Histidine decarboxylase
- SLC6A4: H3 autoreceptor
- H1R-H4R: Histamine receptors
- Soma size: Medium, 15-20 μm
- Dendrites: Extensive
- Axonal varicosities: Dense
- Histamine release: Promotes arousal
- H1 receptors: Excitatory
- Anti-histamines: Sedation
- Food intake: Appetite regulation
- Metabolism: Energy expenditure
- H3 autoreceptors: Modulate release
- TMN degeneration: In narcolepsy
- Hypocretin loss: Downstream effect
- Treatment: Histamine agonists
- Histaminergic deficits: Cognitive decline
- Wakefulness: Sleep disturbances
- Therapeutic potential: Histamine modulation
¶ Allergy and Inflammation
- Blood-brain barrier: Histamine effects
- Neuroinflammation: H1R activation
- Haas. Histamine in brain (2008)
- Passani. Histamine and cognition (2007)