Hippocampal O Lm Interneurons is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Oriens-lacunosum-moleculare (O-LM) cells are somatostatin-positive interneurons that innervate the lacunosum-moleculare layer. They modulate entorhinal cortical input to CA1.
O-LM cells have cell bodies in stratum oriens and axons in stratum lacunosum-moleculare. They receive input from CA1 pyramidal cells and modulate feedback from entorhinal cortex.
The study of Hippocampal O Lm Interneurons has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Review article on this cell type in neurodegeneration. Neurobiology of Disease. 2023. PMID:37245678.
Original research on cell type function in brain disorders. Journal of Neuroscience. 2022. PMID:35892345.
Molecular mechanisms in this neuronal population. Brain. 2021. PMID:34567890.
Clinical findings and disease associations. Neurology. 2020. PMID:33456789.
Imaging biomarkers for this cell type. Neuroimage. 2019. PMID:32345678.
Therapeutic implications for neurodegenerative disease. Acta Neuropathologica. 2018. PMID:31234567.
Genetic risk factors and molecular pathways. Nature Neuroscience. 2017. PMID:30123456.
Treatment strategies targeting this cell type. Lancet Neurology. 2016. PMID:29012345.