Gonadotropin-secreting pituitary adenomas (non-functioning) often present with mass effects rather than hormone excess.
These adenomas:
- Secrete inactive gonadotropins
- Often discovered incidentally
- Present with hypogonadism
- Preoptic area
- Arcuate nucleus
- Regulate LH/FSH secretion
- Pulsatile secretion critical
- Disrupted by mass effect
- Compression effects
- Reduced pulsatility
- Secondary hypogonadism
- Reduced testosterone/estrogen effects
- Mood changes
- Memory effects
- Feedback disruption
- Appetite regulation changes
- Sleep alterations
- Headache
- Visual field defects
- Hypopituitarism
- Decreased libido
- Erectile dysfunction
- Amenorrhea
- Fatigue
- Non-functioning adenomas (2022)
- GnRH and CNS (2021)