Glutamate Receptors In Neuronal Function is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Glutamate is the primary excitatory neurotransmitter in the CNS. Its receptors mediate fast synaptic transmission and plasticity.
The study of Glutamate Receptors In Neuronal Function has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Traynelis SF, Wollmuth LP, McBain CJ, Menniti FS, Vance KM, et al. "Glutamate receptor ion channels: structure, regulation, and function." Pharmacol Rev. 2010;62(3):405-496. DOI:10.1124/pr.109.002451
Mayer ML. "Glutamate receptors at atomic resolution." Nature. 2016;540(7634):433-440. DOI:10.1038/nature20568
Hollmann M, Heinemann S. "Cloned glutamate receptors." Annu Rev Neurosci. 1994;17:31-108. DOI:10.1146/annurev.ne.17.030194.000431
Dingledine R, Borges K, Bowie D, Traynelis SF. "The glutamate receptor ion channels." Pharmacol Rev. 1999;51(1):7-61. PMID:10049997
Kim E, Sheng M. "AMPA receptor subunit composition in dendritic spines." Nat Neurosci. 2004;7(5):429-437. DOI:10.1038/nn1211