GAD produces GABA and marks GABAergic inhibitory neurons.
| Property |
Value |
| Category |
GABAergic Neurons |
| Location |
Throughout CNS |
| Enzyme |
Glutamate decarboxylase |
| Transmitter |
GABA |
- GAD65: Synaptic vesicles
- GAD67: Cytosolic
- Pyridoxal phosphate: Cofactor
- GAD1: GAD67
- GAD2: GAD65
- Developmental: Expression
- Interneurons: Various types
- Parvalbumin: Fast-spiking
- Somatostatin: Dendrite-targeting
- Purkinje cells: GABAergic
- Stellate/basket: Inhibitory
- Golgi: Granule layer
- Network balance: E/I
- Seizure suppression: Critical
- Oscillations: Gamma, etc.
- Memory: Hippocampal
- Attention: Cortical
- Motor learning: Cerebellar
- GAD: Autoantibody
- Seizures: GAD in
- Therapeutic: GABA enhancement
- GAD: Reduced expression
- GABA: Dysfunction
- Therapeutic: GABA targeting
- Erlander. GAD genes (1991)
- Buonanno. GAD and GABA (2010)