Gaba Receptors In Neuronal Inhibition is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
GABA is the primary inhibitory neurotransmitter in the CNS. Its receptors mediate inhibition and are dysregulated in neurodegeneration.
- Ligand-gated chloride channel: Fast inhibition
- Subunits: α1-6, β1-3, γ1-3, δ, π, ρ
- Location: Synaptic and extrasynaptic
- Benzodiazepine site: Allosteric modulator
- Metabotropic: G protein-coupled
- Presynaptic: Inhibit release
- Postsynaptic: Hyperpolarization
- Kainate modulation: Cross-talk
- Inhibition: Reduce neuronal firing
- Oscillations: Gamma, sharp waves
- Plasticity: Inhibitory plasticity
- Balance: E/I balance
- Protection: Anti-excitotoxicity
- GABAergic loss: Reduced interneurons
- Network dysfunction: Hyperexcitability
- Seizures: Comorbidity
- Inhibition changes: Basal ganglia circuits
- DBS mechanisms: GABAergic modulation
- Sieghart W, Sperk G. (2002). Subunit composition, distribution and function of GABA-A receptor subtypes. Curr Top Med Chem. DOI:10.2174/1568026023393507
The study of Gaba Receptors In Neuronal Inhibition has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
- Bormann J. (2000). The ABC of GABA receptors. Trends Pharmacol Sci. PMID:10650358. https://pubmed.ncbi.nlm.nih.gov/10650358/
- Sieghart W, Sperk G. (2002). Subunit composition, distribution and function of GABA-A receptor subtypes. Curr Top Med Chem. PMID:11945129. https://pubmed.ncbi.nlm.nih.gov/11945129/
- Cherubini E, Conti F. (2001). Generating diversity at GABAergic synapses. Trends Neurosci. PMID:11515195. https://pubmed.ncbi.nlm.nih.gov/11515195/
- Möhler H. (2006). GABAergic neurons: decoding the logic of inhibitory circuits. Brain Res. PMID:16524597. https://pubmed.ncbi.nih/16524597/
- Farrant M, Nusser Z. (2005). Variations on an inhibitory theme: phasic and tonic activation of GABA_A receptors. Nat Rev Neurosci. PMID:15821740. https://pubmed.ncbi.nlm.nih.gov/15821740/
- Whiting PJ. (2003). GABA-A receptor subtypes in the brain: a paradigm for CNS drug discovery? Drug Discov Today. PMID:14519162. https://pubmed.ncbi.nlm.nih.gov/14519162/
- Rudolph U, Möhler H. (2004). GABA-based therapeutic approaches: GABA_A receptor subtype functions. Curr Opin Pharmacol. PMID:14602450. https://pubmed.ncbi.nlm.nih.gov/14602450/
- Jacob TC, Moss SJ, Jurd R. (2008). GABA(A) receptor trafficking and the molecular pathology of epilepsy. Neuropharmacology. PMID:17928081. https://pubmed.ncbi.nlm.nih.gov/17928081/