Focused ultrasound (FUS) can thermally ablate or neuromodulate brain tissue non-invasively.
FUS uses:
- High-intensity for ablation
- Low-intensity for neuromodulation
- Precise targeting
- Skull-penetrating waves
- VIM nucleus
- Essential tremor
- Tremor relief
- GPi
- Parkinson's disease
- Dyskinesia reduction
- Anterior limb
- OCD
- Refractory cases
- Modulation without ablation
- Targeted regions
- Temporal precision
- Functional connectivity
- Distributed changes
- Non-invasive
- Protein denaturation
- Coagulation necrosis
- Permanent effects
- Pressure effects
- Cavitation (with contrast)
- Mechanical disruption
- Mechanical effects
- Ion channel activation
- Synaptic modulation
- VIM thalamotomy
- Significant improvement
- FDA approved
- GPi ablation
- Motor symptoms
- Tremor dominant
- Anterior capsulotomy
- Refractory cases
- Clinical trials
- Opening BBB
- Drug delivery
- Clinical trials
- Procedure risks
- Intracranial hemorrhage
- Rare with modern systems
- Generally very safe
- Minimal side effects
- Promising
- Focused ultrasound for movement disorders (2022)
- LIFU neuromodulation (2021)