D2 receptor-expressing neurons mediate inhibitory dopamine signaling and motor control.
| Property |
Value |
| Category |
Dopamine Receptor Neurons |
| Location |
Striatum, VTA, Cortex |
| Receptor Type |
D2 (DRD2) |
| Signaling |
Gi-coupled, inhibitory |
- D2S: Presynaptic autoreceptor
- D2L: Postsynaptic receptor
- Splicing: Alternative splicing
- Striatum: Indirect pathway (D2-MSNs)
- VTA: Autoreceptors
- Pituitary: Prolactin inhibition
- Gi protein: Inhibits adenylate cyclase
- cAMP: Decreases intracellular cAMP
- Arrestin: Beta-arrestin pathway
- Autoreceptor: Negative feedback
- Vesicle release: Reduced dopamine
- Synthesis: Tyrosine hydroxylase inhibition
- Indirect pathway: D2-MSNs suppress movement
- Hyperkinetic: D2 blockade causes dyskinesia
- Parkinson's: D2 agonist therapy
- VTA D2: Negative reward signals
- Aversion: D2 activation
- Addiction: D2 receptor changes
- D2 agonists: Pramipexole, ropinirole
- D2 dysfunction: Motor symptoms
- DBS effects: D2 pathway modulation
- D2 antagonists: Typical antipsychotics
- D2 blockade: Therapeutic effect
- EPS: D2过度blockade
- Beaulieu. D2 receptor signaling (2011)
- Ginovart. D2 receptor imaging (2007)