Disease Associated Oligodendrocytes is an important cell type in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Disease-associated oligodendrocytes (DOLs) are a recently characterized population of oligodendrocytes that accumulate in neurodegenerative conditions. These cells exhibit a distinct transcriptional profile and contribute to demyelination, axonal dysfunction, and disease progression.
This page provides comprehensive information about the subject's role in neurodegenerative diseases. The subject participates in various molecular pathways and cellular processes relevant to Alzheimer's disease, Parkinson's disease, and related conditions.
- Distended soma
- Process retraction
- Myelin sheath disruption
- Cytoplasmic inclusions
- Upregulated stress genes
- Complement component expression
- Iron metabolism genes
- MHC class II presentation
- Reduced MBP expression
- Altered PLP processing
- Defective lipid synthesis
- Transport deficits
- Myelin breakdown products
- Phagocytic clearance
- Remyelination failure
- Progressive demyelination
- Energy metabolite loss
- Neurotrophic factor reduction
- Ionic imbalance
- Axonal transport disruption
- Complement activation
- Cytokine production
- Antigen presentation
- Phagocytic activity
- Oligodendrocyte loss in white matter
- Reduced myelin density
- Impaired lactate transport
- White matter hyperintensities
- Amyloid distribution
- Tau propagation
- Neuroinflammation
- Cognitive decline correlation
- Nigral white matter changes
- Demyelination in PD brains
- Oligodendrocyte vulnerability
- Iron accumulation
- Dopaminergic axonal degeneration
- Myelin lipid peroxidation
- Oxidative stress
- Mitochondrial dysfunction
- Primary target of autoimmunity
- Active demyelination
- Chronic lesions
- Failure of remyelination
- Pre-lesional changes
- Compartmentalized inflammation
- Neurodegeneration
- Myelin-promoting compounds
- Remyelination enhancers
- Oligodendrocyte survival factors
- Complement inhibitors
- Cytokine blockers
- Microglial modulators
- Lactate supplementation
- Mitochondrial function
- Energy metabolism
- Human iPSC oligodendrocytes
- Patient-derived cells
- CRISPR models
- Animal oligodendrocyte culture
- Cuprizone model
- EAE model
- Transgenic demyelination
- Aging models
- Myelin basic protein
- Myelin oligodendrocyte glycoprotein
- Choline-containing compounds
- White matter tractography
- Myelin water imaging
- Magnetization transfer
The study of Disease Associated Oligodendrocytes has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
- Jäkel et al., Disease-associated oligodendrocytes (2019)
- Stadelmann et al., Oligodendrocyte dysfunction in disease (2019)
- Simons & Nave, Oligodendrocytes: function and pathology (2015)
- Bradl & Lassmann, Oligodendrocytes in disease (2010)