D1 and D5 receptors are D1-like dopamine receptors that are excitatory and mediate reward and motor control.
| Property |
Value |
| Category |
Dopamine Receptor Neurons |
| Location |
Striatum, Cortex, Nucleus accumbens |
| Receptor Type |
D1 (DRD1), D5 (DRD5) |
| Signaling |
Gs-coupled, excitatory |
- Family: D1-like (D1, D5)
- G protein: Gs/olf
- cAMP: Increases
- Striatum: Medium spiny neurons
- NAc: Shell and core
- Cortex: Layer 2/3
- Motivation: Enhancement
- Reinforcement: Critical
- Learning: Reward prediction
- Movement: Initiation
- Bradykinesia: D1 in PD
- Dyskinesia: Overstimulation
- D1 agonists: Treatment
- Motor symptoms: Improvement
- Dyskinesia: Side effect
- D1: Working memory
- Hypofrontality: D1 deficit
- Therapeutic: Targeting D1
- Missale et al., D1 receptors (1998)
- Sibley, D1-like receptors (1999)