CRF receptor-expressing neurons are central to stress responses and have been implicated in stress-related neurodegeneration.
CRF acts through CRF1 and CRF2 receptors. CRF1 is primarily associated with stress and anxiety responses.
CRF receptor neurons are found in:
Chronic stress and elevated CRF may accelerate AD pathology. CRF receptor antagonists are being explored.
Stress exacerbates PD symptoms; CRF modulation may have therapeutic benefit.
CRF system dysregulation observed in ALS models.