CGRP is a potent neuropeptide involved in migraine, pain, and cardiovascular regulation.
| Property |
Value |
| Category |
Tachykinin-like Neurons |
| Location |
Trigeminal ganglion, Spinal cord |
| Neuropeptide |
CGRP |
| Receptors |
CALCRL/RAMP1 |
- CGRP: 37 amino acids
- Alpha-CGRP: Neural tissue
- Beta-CGRP: Gut, other
- Trigeminal: Migraine pathway
- Dorsal horn: Pain transmission
- Ventral tegmentum: Reward circuits
- Nociception: Pain signaling
- Hyperalgesia: Sensitization
- Migraine: CGRP in migraine
- Blood vessels: Potent dilator
- Neurogenic inflammation: CGRP effects
- Headache: Migraine mechanism
- CGRP antagonists: Gepants
- CGRP antibodies: Preventive
- Therapeutic: CGRP targeting
- CGRP: Inflammatory pain
- Arthritis: CGRP role
- Therapeutic: CGRP modulation
- Brain. CGRP discovery (1985)
- Rosenfeld. CGRP gene (1983)