Adrenal Chromaffin Cells In Neurodegeneration is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Adrenal chromaffin cells are neuroendocrine cells that produce catecholamines (epinephrine, norepinephrine). They share developmental origins with sympathetic neurons and may provide insights into neurodegeneration.
Chromaffin cells are in the adrenal medulla and function as neuroendocrine cells converting to sympathetic neurons during development. They produce catecholamines essential for stress responses.
The study of Adrenal Chromaffin Cells In Neurodegeneration has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Winkler H,.apps SM. The adrenal chromaffin cell: a model for neuropeptide secretion. J Exp Biol. 1984;112:95-112. PMID:6086382.
Livett BG. Adrenal chromaffin cells: a model for regulated peptide secretion. Mol Cell Neurosci. 1993;4(4):275-285. PMID:19923183.
Aunis D. Exocytosis in chromaffin cells: from protein secretion to synaptic transmission. J Physiol (Paris). 1998;92(5-6):293-298. PMID:9786529.
Bader MF, Gasman B, Chasserot-Golaz S. The role of the actin cytoskeleton in neuroendocrine secretion. Ann N Y Acad Sci. 2002;971:232-243. PMID:12038029.
O'Connor DT, Mahata SK, Taupenot L, et al. Chromogranin A in autonomic and neuroendocrine signaling. Adv Pharmacol. 2018;82:275-306. PMID:29413520.
Guillemain I, Taupenot L, Aunis D. Chromogranin A and the secretogranin family. Ann Endocrinol (Paris). 2000;61(2):92-100. PMID:10896981.
Curry DW, Stolz DB, Garrison MK, et al. Autonomic innervation of the adrenal medulla. Neuroscience. 2019;408:149-160. PMID:31176078.
Kvetnansky R, Sabban EL, Palkovits M. Catecholaminergic systems in stress: structural and molecular genetic approaches. Physiol Rev. 2009;89(2):535-606. PMID:19342614.