Adiponectin is an adipokine with metabolic and neuroprotective effects.
| Property |
Value |
| Category |
Metabolic Hormone Neurons |
| Location |
Hypothalamus, Cortex |
| Hormone |
Adiponectin (ADIPOQ) |
| Receptors |
AdipoR1, AdipoR2 |
- Adiponectin: Collagen-like protein
- Multimers: Trimer, hexamer, HMW
- Adipocyte-derived: Fat hormone
- AdipoR1: High affinity
- AdipoR2: Intermediate
- T-cadherin: Co-receptor
- Glucose: Insulin sensitivity
- Fatty acid oxidation: AMPK activation
- Energy: Expenditure
- AMPK activation: Energy sensing
- Mitochondrial: Biogenesis
- Inflammation: Anti-inflammatory
- Adiponectin: Low in obesity
- Insulin sensitivity: Therapeutic target
- Therapeutic: Adiponectin agonists
- Adiponectin: Mood effects
- Inflammation: AD and depression
- Therapeutic: Targeting
- Scherer. Adiponectin (1995)
- Kadowaki. Adiponectin receptors (2006)