Olfactory Bulb Neurons In Parkinson'S Disease is a cell type relevant to neurodegenerative disease research. This page covers its role in brain function, involvement in disease processes, and significance for therapeutic strategies.
Olfactory bulb neurons are among the earliest and most significantly affected populations in Parkinson's disease, with olfactory dysfunction (hyposmia) often predating motor symptoms by years. The olfactory bulb shows some of the earliest Lewy pathology in PD, making it a critical window into disease progression.
Based on Braak staging, olfactory bulb involvement occurs in Stage 1-2:
Olfactory bulb → Anterior olfactory nucleus →
Olfactory tubercle → Limbic system → Brainstem
The study of Olfactory Bulb Neurons In Parkinson'S Disease has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Hawkes CH, Shephard BC, Daniel SE. Olfactory dysfunction in Parkinson's disease. J Neurol Neurosurg Psychiatry. 1997;62(5):436-446. PMID:9166403.
Doty RL. Olfactory dysfunction in Parkinson disease. Nat Rev Neurol. 2012;8(6):329-339. PMID:22614258.
Braak H, Del Tredici K, Rüb U, de Vos RA, Jansen Steur EN, Braak E. Staging of brain pathology related to sporadic Parkinson's disease. Neurobiol Aging. 2003;24(2):197-211. PMID:12498954.
Wilson RS, Yu L, Schneider JA, et al. Olfactory impairment in the spectrum of mild cognitive impairment and Alzheimer's disease. J Int Neuropsychol Soc. 2011;17(2):277-285. PMID:21205405.
Mahlknecht P, Poehler W, Marini K, et al. Olfactory symptoms and olfactory testing for diagnosis of Parkinson's disease. J Neurol. 2015;262(8):1884-1893. PMID:26054563.
Haehner A, Hummel T, Reichmann H. Olfactory dysfunction as a diagnostic marker for Parkinson's disease. Expert Rev Neurother. 2011;11(12):1771-1779. PMID:22150327.
Garcia-Esparcia P, Llorens F, Módena D, et al. Prion-like properties of α-synuclein in the olfactory system of patients with Parkinson's disease. Acta Neuropathol. 2013;126(5):695-709. PMID:24174162.
Rey NL, Wesson DW, Brundin P. The olfactory bulb as the entry point for alpha-synuclein propagation in Parkinson's disease. Brain. 2018;141(4):972-983. PMID:29378013.