Hippocampal Ca2 Neurons In Alzheimer'S Disease is a cell type relevant to neurodegenerative disease research. This page covers its role in brain function, involvement in disease processes, and significance for therapeutic strategies.
The hippocampal CA2 region has emerged as particularly vulnerable in Alzheimer's disease, with recent research highlighting its unique molecular profile and early involvement in AD pathology.
| Feature | CA1 | CA2 | CA3 |
|---|---|---|---|
| Tau pathology | High | Highest | Moderate |
| amyloid deposition | Moderate | High | Low |
| Neuron loss | Moderate | High | Low |
The study of Hippocampal Ca2 Neurons In Alzheimer'S Disease has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Armstrong DM, Sheffield R, Kawaguchi K, et al. Abnormalities of hippocampal CA2 neurons in Alzheimer's disease. Exp Neurol. 1993;120(1):100-108. PMID:8474486.
Limon A, Reyes-Ruiz JM, Miledi R. Loss of functional GABA(A) receptors in the Alzheimer diseased hippocampus. Brain. 2012;135(Pt 10):2984-2994. PMID:22945519.
McQuail JA, Burke CA, Behnisch M, et al. Region-specific changes in hippocampal CA2 calcium signaling. Neurobiol Aging. 2015;36(2):720-733. PMID:25448601.
Hitti FL, Siegelbaum SA. The hippocampal CA2 region is essential for social memory. Nature. 2014;508(7494):88-92. PMID:24572357.
Zhao M, Choi SH, Obrietan K, Yang Y. Synaptic plasticity and neuronal death in the hippocampal CA2 region. Neural Plast. 2016;2016:4125237. PMID:26949853.
Boehringer R, Polygalov D, Huang AJY, et al. Chronic dim light alters the hippocampal CA2 transcriptome. J Neurosci Res. 2017;95(11):2194-2209. PMID:28613834.
Mercer A, Riggall C, Empson L, Wann M, Torborg CL, Frampton D. The hippocampal CA2 region. Brain Res Bull. 2015;119(Pt A):41-51. PMID:25577023.
Williamson LL, Bilbo SD. Chemokines and the hippocampus: a new view on hippocampal inflammation. Prog Neuropsychopharmacol Biol Psychiatry. 2013;45:47-55. PMID:23665163.