Cerebellar Granule Cells In Alzheimer'S Disease is a cell type relevant to neurodegenerative disease research. This page covers its role in brain function, involvement in disease processes, and significance for therapeutic strategies.
Cerebellar granule cells, the most abundant neurons in the brain, are increasingly recognized as affected in Alzheimer's disease. While traditionally associated with ataxia, the cerebellum shows connections to cognitive networks and may contribute to AD symptoms.
The study of Cerebellar Granule Cells In Alzheimer'S Disease has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
S joblom-Widfelt E, Vilson F, Landgren S. Cerebellar involvement in Alzheimer's disease. Acta Neurol Scand. 1989;79(5):352-355. PMID:2728882.
Wegiel J, Wisniewski HM, Dziedzic T, et al. Cerebellar atrophy in Alzheimer's disease. Neuropathology. 1999;19(4):386-394. PMID:10575495.
Mavroudis IA, Fotiou DF, Adipietro K, et al. Cerebellar pathology in patients with Alzheimer's disease. Clin Neurol Neurosurg. 2012;114(7):842-848. PMID:22425010.
Ghez C, Thach WT. The cerebellum. In: Kandel ER, Schwartz JH, Jessell TM, eds. Principles of Neural Science. 4th ed. New York: McGraw-Hill; 2000:832-852.
Schmahmann JD. The cerebellum and cognition. Int Rev Neurobiol. 1997;41:191-223. PMID:9378622.
Jacobs B, Driscoll L, Schall M. Life-span dendritic and synaptic changes in human premotor cortex. J Comp Neurol. 1999;406(3):299-320. PMID:10102499.
Inoue M, Yuzaki M, Shigemoto R. Cerebellar long-term depression. Mol Cell Neurosci. 2004;25(2):258-270. PMID:15019943.
O'Halloran CJ, Kinsella G, STOREY E. Impaired executive function and memory in cerebellar disease. Cerebellum. 2012;11(1):1-13. PMID:21431467.