5-HT6 is an excitatory serotonin receptor highly expressed in the striatum and hippocampus, involved in cognition.
| Property |
Value |
| Category |
Serotonin Receptor Neurons |
| Location |
Striatum, Hippocampus, Cortex |
| Receptor Type |
5-HT6 |
| Signaling |
Gs-coupled, excitatory |
- Family: 5-HT6
- G protein: Gs
- cAMP: Increases
- Striatum: High expression
- Hippocampus: CA1-3
- Cortex: All layers
- Learning: Facilitation
- Memory: Enhancement
- Executive function: Role in striatum
- Striatum: Movement
- Parkinson's: Therapeutic target
- Dyskinesia: Modulation
- 5-HT6: Memory enhancement
- Cognitive deficits: Target
- Therapeutic: Idalopirdine, SB-742457
- 5-HT6: Cognition
- Negative symptoms: Target
- Therapeutic: Potential
- Ries et al., 5-HT6 antagonists (2008)
- Ward et al., 5-HT6 in cognition (2011)